GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs111803315 | 1 | rs112555934 | chr14:59977232 | C14orf149 | chr14:59939406-59951126:- | -0.26 | -3.8 | 0.000153 | Schizophrenia |
| BRCA | cis | rs111803315 | 1 | rs112555934 | chr14:59977232 | JKAMP | chr14:59951161-59972080:+ | 0.32 | 5.6 | 2.76E-8 | Schizophrenia |
| BRCA | cis | rs1853207 | 1 | rs112573749 | chr10:96547736 | C10orf129 | chr10:96953957-96988685:+ | 0.32 | 5.36 | 1.03E-7 | Blood metabolite levels |
| BRCA | cis | rs11258317 | 1 | rs11258317 | chr10:6407737 | RBM17 | chr10:6130949-6159420:+ | 0.11 | 3.57 | 0.000376 | Bipolar disorder and schizophrenia |
| BRCA | cis | rs8030379 | 1 | rs11259936 | chr15:84580582 | GOLGA6L5 | chr15:85047738-85060078:- | 0.13 | 4.31 | 1.78E-5 | Waist circumference adjusted for body mass index;Waist circumference |
| BRCA | cis | rs8030379 | 1 | rs11259936 | chr15:84580582 | LOC388152 | chr15:84867600-84898920:- | 0.12 | 3.82 | 0.000144 | Waist circumference adjusted for body mass index;Waist circumference |
| BRCA | cis | rs6684514 | 1 | rs11264462 | chr1:156241728 | BGLAP | chr1:156182784-156213112:+ | 0.18 | 4.68 | 3.25E-6 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs11264464 | chr1:156250887 | BGLAP | chr1:156182784-156213112:+ | 0.21 | 5.54 | 3.71E-8 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs11264464 | chr1:156250887 | C1orf85 | chr1:156259882-156265449:- | -0.11 | -3.52 | 0.000457 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs11264467 | chr1:156273061 | BGLAP | chr1:156182784-156213112:+ | -0.12 | -3.39 | 0.000722 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs11264467 | chr1:156273061 | C1orf85 | chr1:156259882-156265449:- | 0.12 | 4.09 | 4.64E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs11264468 | chr1:156274585 | BGLAP | chr1:156182784-156213112:+ | 0.2 | 5.21 | 2.27E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs11264468 | chr1:156274585 | C1orf85 | chr1:156259882-156265449:- | -0.11 | -3.44 | 0.000613 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs11264468 | chr1:156274585 | CCT3 | chr1:156278752-156308195:- | -0.11 | -3.45 | 0.000576 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs111803315 | 1 | rs112661971 | chr14:59901054 | C14orf149 | chr14:59939406-59951126:- | -0.3 | -4.29 | 1.98E-5 | Schizophrenia |